期刊
SCIENCE
卷 303, 期 5661, 页码 1195-1198出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1092341
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资金
- NIDDK NIH HHS [P60 DK20541, P01 DK49210, P30 DK19525] Funding Source: Medline
- NIGMS NIH HHS [NIH T32-GM008216] Funding Source: Medline
The association between obesity and diabetes supports an endocrine role for the adipocyte in maintaining glucose homeostasis. Here we report that mice lacking the adipocyte hormone resistin exhibit low blood glucose levels after fasting, due to reduced hepatic glucose production. This is partly mediated by activation of adenosine monophosphate-activated protein kinase and decreased expression of gluconeogenic enzymes in the liver. The data thus support a physiological function for resistin in the maintenance of blood glucose during fasting. Remarkably, lack of resistin diminishes the increase in post-fast blood glucose normally associated with increased weight, suggesting a role for resistin in mediating hyperglycemia associated with obesity.
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