期刊
JOURNAL OF THEORETICAL BIOLOGY
卷 226, 期 4, 页码 477-482出版社
ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jtbi.2003.10.006
关键词
caspar-klug theory; viral capsids; polyoma virus; L-A virus
资金
- Engineering and Physical Sciences Research Council [GR/S51936/01] Funding Source: researchfish
A novel approach for the description of the protein stoichiometry of viral capsids, that is the protein shells protecting the viral genome, is introduced based on tiling theory. This approach generalizes Caspar-Klug theory of quasi-equivalence to account also for non-quasi-equivalent subunit arrangements in icosahedral virus capsids that have been observed experimentally but are not covered by the Caspar-Klug approach. In particular, the new approach is used to explain the structure of polyoma virus, Simian Virus 40 and L-A virus capsids, which are considered structural puzzles in view of Caspar-Klug theory. (C) 2003 Elsevier Ltd. All rights reserved.
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