期刊
FEBS LETTERS
卷 560, 期 1-3, 页码 51-55出版社
WILEY
DOI: 10.1016/S0014-5793(04)00069-9
关键词
rhinovirus; picornavirus; 2A proteinase; eIF4GI cleavage; caspase inhibitor; apoptosis
Peptide-based fluoromethyl ketones have been considered for many years to be highly specific caspase inhibitors distinctly blocking the progress of apoptosis in a variety of systems. Here we demonstrate that these compounds can significantly reduce rhinovirus multiplication in cell culture. In their methylated forms they block eIF4GI cleavage in vivo and in vitro and inhibit the activity of picornaviral 2A proteinases (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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