期刊
NEUROREPORT
卷 15, 期 3, 页码 569-574出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200403010-00037
关键词
anorexia; hypothalamus; immunohistochemistry; in situ hybridization
Membrane-type-I matrix metalloproteinase (MTI-MMP) knockout (KO) mice fail to gain weight and die 3-4 weeks after birth. To understand the wasting phenotype in MTI-MMP-KO mice we studied the expression of some hypothalamic neuropeptides involved in control of appetite and body weight. In MTI-MMP-KO mice, neuronal perikarya in the arcuate nucleus displayed accumulations of NPY and agouti-related protein (AgRP) immunoreactivity (-ir). In contrast, NPY-ir and AgRP-ir were reduced in the projection areas of the arcuate neurons. NPY and AgRP are known to relay metabolic signals from the periphery into the brain to stimulate body weight gain. Their altered subcellular distribution suggests that MTI-MMP is involved in postnatal development of the arcuate NPY/AgRP-systenn which may contribute to the generation of the wasting phenotype.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据