期刊
SURVEY OF OPHTHALMOLOGY
卷 49, 期 -, 页码 S19-S25出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.survophthal.2003.12.016
关键词
bimatoprost; comparative study; diurnal; intraocular pressure; latanoprost; prospective studies; responder rates
In glaucoma and ocular hypertension, clinically relevant intraocular pressure lowering due to a new medication is frequently defined as at least a 15% or 20% reduction from baseline intraocular pressure. This report compares the percentages of treated patients achieving such reductions in intraocular pressure after 6 months of treatment with bimatoprost or latanoprost. In the previously published study (Noecker et al: A six-month randomized clinical trial coin paring the intraocular pressure-lowering efficacy of bimatoprost and latanoprost in patients with ocular hypertension or glaucoma., Am j Ophthalmol 135:55-63, 2003), patients with glaucoma or ocular hypertension were randomly assigned to once-daily treatment with bimatoprost 0.03% (n = 133) or latanoprost 0.005% (n = 136), after washout of any previous glaucoma medications. The primary outcome measure of that study was mean change from baseline intraocular pressure. The secondary, post hoc analysis presented here compares the diurnal and long-term responder rates observed with bimatoprost and latanoprost patients. Diurnal responders were defined as patients who achieved at least a 15% or 20% reduction from baseline intraocular pressure at each of the three timepoints (8 AM, 12 Pm, and 4 Pm) on a given visit. At week 1 and months 1, 3, and 6, in the bimatoprost group, 70.7-81.2% or patients achieved at least a 15% reduction in IOP at each timepoint, and 57.9-68.4% achieved at least a 20% reduction. Significantly fewer patients receiving latanoprost achieved a 15% or a 20% decrease in IOP at each timepoint: 48.561.8% of patients achieved at least a 15% decrease and 36.0-47.1 % achieved at least a 20% decrease. (P less than or equal to .007). The data presented here suggest that patients using bimatoprost are more likely than patients using latanoprost to achieve intraocular pressure reductions of at least 15% or 20% frorn baseline throughout the day. (Surv Ophthalmol 49(Suppl 1):S19-S25, 2004. (C) 2004 Elsevier Inc. All rights reserved.).
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