期刊
BIOLOGICAL & PHARMACEUTICAL BULLETIN
卷 27, 期 3, 页码 426-428出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.27.426
关键词
Liquidambar formosana; NFAT transcription factor; inhibitory effect; triterpenoid
In a search for inhibitory components from natural products against NFAT transcription factor, this study investigated the ethyl acetate extract of the fruits of Liquidambar formosana. Four oleanane triterpenoids were isolated and identified to be liquidambaric acid, oleanolic acid, 3alpha-acetoxy-25-hydroxy-olean-12-en-28-oic acid and lantanolic acid. Of these compounds, 3alpha-acetoxy-25-hydroxy-olean-12-en-28-oic acid (IC50: 4.63 muM) and lantanolic acid (IC50: 12.62 muM) exhibited strong inhibitory activity against the NFAT transcription factor.
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