期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 42, 期 3, 页码 509-516出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2003.10.016
关键词
Ardisia compressa; chemoprevention; liver cancer; apoptosis
This study evaluates the chemopreventive effect of an aqueous extract of dried leaves of Ardisia compressa against liver cancer. A rat liver assay that mimics progressive forms of human disease was used as a carcinogenesis model. Forty-five male Wistar rats (180-200 g body weight) were injected intraperitoneally on day 1 with a single dose (100 mg/kg) of diethylnitrosamine (DEN), and also received via gavage 20 mg/kg acetylaminofluorene (2-AAF), on days 7, 8 and 9. The rats were randomly divided into four groups (n = 15). Control groups (Group I and Group 2) had free access to water. Group 3 received 0.5% (w/v) of A. compressa tea for 10 days before treatment and during the study as the sole source of fluid until the rats were killed. A fourth group of 15 rats received no carcinogen or promoter but did receive 0.5%, (w/v) of A. compressa tea. All animals had 70% partial hepatectomy at day 10. The incidences of hepatocellular foci, nodules and carcinoma were significantly smaller in Group 3 than in Group 2 (P < 0.01). A. compressa tea consumption alone (Group 4) did not induce the development of foci, nodules or carcinomas (P < 0.01). The striking observation of this study was that consumption of A. compressa tea resulted in complete inhibition of the chemically-induced hepatocarcinogenesis in Wistar rats. (C) 2003 Elsevier Ltd. All rights reserved.
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