期刊
ARCHIVES OF DERMATOLOGY
卷 144, 期 7, 页码 873-877出版社
AMER MEDICAL ASSOC
DOI: 10.1001/archderm.144.7.873
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- NIAMS NIH HHS [P01 AR048564-06A16381] Funding Source: Medline
Objective: To determine which venous malformations (VMS) are at risk for coagulopathy. Venous malformations are slow-flow vascular malformations present at birth, and localized intravascular coagulopathy (LIC) causes pain and thrombosis within a lesion and severe bleeding during surgical procedures. Design: Prospective convenience sample accrued from 2 multidisciplinary sites in Brussels, Belgium, and Caen, France. Participants: The study population comprised 140 patients with clinical data and coagulation parameters. Magnetic resonance imaging was performed for 110 patients. Main Outcome Measure: Measurement of D-dimer levels. Results: Of the 140 participants, 59 (42%) showed high D-dimer levels, 36 (61%) of whom had levels higher than 1.0 mu g/mL. Six of the participants had low fibrinogen levels. In univariate analysis, large surface, presence of palpable phleboliths, and truncal localization were associated with high D-dimer levels. In the multivariate analysis, only large surface area and presence of phleboliths remained independently associated with high D-dimer levels. Severe LIC, characterized by concomitant low fibrinogen level, was associated with extensive venous malformations of the extremities. Conclusions: Localized intravascular coagulopathy is statistically significantly associated with large and/or deep venous malformations that affect any location, which can have palpable phlebolith. These patients are at risk of local pain due to thrombosis. Lesions with elevated D-dimer levels associated with low fibrinogen levels (severe LIC) commonly affect an extremity and have a high risk of hemorrhage. Low-molecular-weight heparin can be used both to treat the pain caused by LIC and to prevent decompensation of severe LIC to disseminated intravascular coagulopathy.
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