期刊
NEUROBIOLOGY OF AGING
卷 25, 期 3, 页码 407-416出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2003.12.001
关键词
normal aging; age-related learning deficits; hippocampus; perforated synapses; nonperforated synapses; postsynaptically silent synapses
资金
- NIA NIH HHS [R37 AG 08796, P01 AG 09973, 5R01 AG17139] Funding Source: Medline
The aim of this study was to determine whether spatial learning deficits in aged rats are associated with a loss of hippocampal synapses. The Morris water maze task was used to assess the spatial learning capacity of young and aged rats and to attribute aged animals to learning-impaired and leaming-unimpaired groups. The number of axospinous synapses in the entire volume of the CA1 stratum radiatum was estimated with unbiased stereological techniques. The results show that the total number of all axospinous synapses and of their perforated and nonperforated subtypes remains constant in the CA1 stratum radiatum of aged learning-impaired rats as compared to aged leaming-unimpaired rats and to young adults. Thus, neither age-related deficits in spatial learning nor advanced chronological age are associated with a loss of axospinous synapses from the rat CA1 stratum radiatum. (C) 2003 Elsevier Inc. All rights reserved.
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