In(OTf)3 catalysed simple one-pot synthesis of α-amino phosphonates

A new efficient one-pot synthesis of alpha-amino phosphonates derived from nitro substituted anilines, aldehydes and diethyl phosphite has been carried out by employing 5 mol% of In(OTf)(3). The method is equally effective for the generation of a-amino phosphonates from various carbonyl compounds and other amines. (C) 2003 Elsevier B.V. All rights reserved.