期刊
MOLECULAR AND CELLULAR NEUROSCIENCE
卷 25, 期 3, 页码 515-523出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.mcn.2003.12.001
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Mice deficient in the extracellular matrix protein tenascin-R (TN-R -/- mice) show several indices of impaired perisomatic inhibition in hippocampal slices. The present study examined electroencephalograms (EEGs) and auditory-evoked potentials (AEPs) in freely moving TN-R-/- and wild-type control mice, focusing on the hippocampal CA1 field and cerebral cortex. TN-R-/- mice expressed normal high-frequency oscillations (ripples) in CA1 and only a slight reduction of peak theta frequency. In contrast, their hippocampal gamma oscillations were significantly enhanced in amplitude. Also, the amplitude of the cortical EEG of TN-R-/-mice was increased over a wide frequency range. The amplitude of cortical and, to a lesser degree hippocampal, AEPs was clearly enhanced in TN-R-/- mice. In addition, response habituation to repeated sound stimuli was significantly attenuated in TN-R-/-mice. These findings indicate that tenascin-R is involved in the regulation of certain inhibitory mechanisms in the intact brain. (C) 2004 Elsevier Inc. All rights reserved.
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