期刊
HIGH PRESSURE RESEARCH
卷 24, 期 1, 页码 57-66出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/08957950310001635828
关键词
proteins; pressure; phase diagram; aggregation; fibril formation
The conditions for temperature and pressure survival of organisms point to proteins as the primary target. The elliptic shape of the stability phase diagram of proteins in aqueous solutions suggests that hydration and packing specificity are important factors. Pressure is a valuable tool for the study of partially unfolded protein conformations that give rise to aggregation and fibril formation.
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