期刊
TRENDS IN PHARMACOLOGICAL SCIENCES
卷 25, 期 3, 页码 113-117出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2004.01.010
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Ghrelin plays a key role as the major orexigenic hormone from the gastrointestinal tract to the hypothalamic areas that govern food intake, balancing against a multitude of anorectic hormones, such as leptin, insulin and PYY3-36. Surprisingly, even in the absence of agonist, the ghrelin receptor signals with similar to50% activity. Thus, although ghrelin receptor antagonists are expected to reduce meal-associated food intake, inverse agonists of the ghrelin receptor, by blocking the constitutive receptor activity, might lower the set-point for hunger between meals, eliminating the craving for second orders, desserts and snacks.
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