期刊
JOURNAL OF INTERNAL MEDICINE
卷 255, 期 3, 页码 351-366出版社
WILEY
DOI: 10.1111/j.1365-2796.2003.01301.x
关键词
cell migration; heparin sulphates; HMG; neurite outgrowth; RAGE; S100
Amphoterin is a ubiquitous and highly conserved protein previously considered solely as a chromatin-associated, nuclear molecule. Amphoterin is released into the extracellular space by various cell types, and plays an important role in the regulation of cell migration, differentiation, tumorigenesis and inflammation. This paper reviews recent research on the mechanistic background underlying the biology of secreted amphoterin, with an emphasis on the role of amphoterin as an autocrine/paracrine regulator of cell migration.
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