期刊
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
卷 29, 期 3, 页码 256-268出版社
OXFORD UNIV PRESS
DOI: 10.1093/arclin/acu010
关键词
Alzheimer's disease; Fluency; Language and language disorders; Executive functioning
资金
- Life Science Discovery Fund of Washington State, National Institute of Bio Medical Imaging and Bioengineering [R01 EB009675]
- Integrative Graduate Education Research Traineeship [DGE-0900781 2009-2014]
The underlying nature of verbal fluency deficits in Alzheimer's disease (AD) was investigated in this study. Participants were 48 individuals with AD and 48 cognitively healthy older adults. Fluency performance on letter and category tasks was analyzed across two 30-s intervals for total words produced, mean cluster size, and total switches. Compared with the control group, AD participants produced fewer words and switches on both fluency tasks and had a reduced category cluster size. The AD group was differentially impaired on category compared with letter fluency and produced more repetitive responses but fewer category exemplars than controls on the category task. A multidimensional scaling approach revealed that AD participants' semantic maps were similar to controls. Overall, the data suggest that executive abilities involving search and retrieval processes and a reduced availability of semantically related words contributed to the AD group's poorer performance despite similar temporal recall and organizational patterns.
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