期刊
PHARMACOTHERAPY
卷 24, 期 3, 页码 415-418出版社
PHARMACOTHERAPY PUBLICATIONS INC
DOI: 10.1592/phco.24.4.415.33182
关键词
Fanconi's syndrome; HIV infection; tenofovir; nephrotoxicity
Tenofovir is a nucleotide reverse transcriptase inhibitor for treatment of human immunodeficiency virus (HIV) infection. Several cases of renal failure associated with tenofovir therapy recently have been reported. A 54-year-old man with HIV experienced decreasing renal function and Fanconi's syndrome secondary to tenofovir therapy. His condition gradually improved after discontinuation of the drug. The available medical literature for reported cases of tenofovir-related nephrotoxicity indicates that this complication is apparently rare. However, our case report and literature review underscore the importance of monitoring renal function when treating patients with any nucleotide reverse transcriptase inhibitor.
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