期刊
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
卷 29, 期 8, 页码 793-805出版社
OXFORD UNIV PRESS
DOI: 10.1093/arclin/acu050
关键词
Dementia; Neurodegenerative diseases; Social behavior; Behavioral assessment; Semantic dementia; Presenile dementia
资金
- National Institutes of Health [R01AG034499-04]
- VA Geriatric Research Education and Clinical Centers (GRECC)
- NATIONAL INSTITUTE ON AGING [R01AG034499] Funding Source: NIH RePORTER
Early social dysfunction is a hallmark symptom of behavioral variant frontotemporal dementia (bvFTD); however, validated measures for assessing social deficits in dementia are needed. The purpose of the current study was to examine the utility of a novel informant-based measure of social impairment, the Socioemotional Dysfunction Scale (SDS) in early-onset dementia. Sixteen bvFTD and 18 early-onset Alzheimer's disease (EOAD) participants received standard clinical neuropsychological measures and neuroimaging. Caregiver informants were administered the SDS. Individuals with bvFTD exhibited greater social dysfunction on the SDS compared with the EOAD group; t(32) = 6.32, p < .001. The scale demonstrated preliminary evidence for discriminating these frequently misdiagnosed groups (area under the curve = 0.920, p = < .001) and internal consistency alpha = 0.977. The SDS demonstrated initial evidence as an effective measure for detecting abnormal social behavior and discriminating bvFTD from EOAD. Future validation is recommended in larger and more diverse patient groups.
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