期刊
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
卷 57, 期 2, 页码 307-312出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0939-6411(03)00188-7
关键词
lidocaine; semisolid formulation; topical delivery; phloretin; permeation enhancer; porcine skin
The purpose of the present study was to determine the significance of phloretin on the topical permeation of lidocaine using different semisolid preparations as delivery systems. One hydrophilic and three lipophilic formulations were used. After estimation of the solubility of phloretin and lidocaine in the vehicles and analysis of the viscoelastic properties, standard diffusion experiments with Franz type diffusion cells through porcine skin were performed. Results indicate a general lidocaine enhancement by phloretin in the tested vehicles. The permeation was enhanced 1.39-fold in the hydrophilic formulation and between 1.25- and 1.76-fold in the lipophilic formulations. (C) 2003 Elsevier B.V. All rights reserved.
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