期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 12, 期 5, 页码 1221-1230出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2003.11.003
关键词
thieno-[3,2-b]-pyrrole; anti-inflammatory; biological activity; rat-paw edema
A series of thiophene [3,2-b] pyrrole derivatives were synthesized and evaluated their abilities to inhibit anti-inflammatory activity. In this series, substituent effects at the N-1, 2 and 5 positions of thiophene [3,2-b] pyrrole were examined. The results obtained are compared to those previously reported anti-inflammatory drugs like Tenidap sodium, Diclofenac sodium and Piroxicam. The results indicated the critical role of the group linked in the N-1 position and 2, 5 positions of thiophene [3,2-b] pyrrole with different functional groups. (C) 2003 Elsevier Ltd. All rights reserved.
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