期刊
ELECTROANALYSIS
卷 16, 期 5, 页码 410-414出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/elan.200302874
关键词
DNA damage; silver solid amalgam electrode; HMDE; alternating current voltammetry
Mercury electrodes modified with supercoiled (sc) DNA have been used as highly sensitive tools for the detection of DNA strand breaks or as sensors for DNA cleaving substances. In this paper we show that silver solid amalgam electrode (AgSAE), in connection with alternating current voltammetry, provides similar information about DNA damage as the hanging mercury drop electrode. The AgSAE can be used for the detection of enzymatic or chemical DNA cleavage in solution or at the electrode surface. AgSAE modified with scDNA can be utilized as a sensor for DNA nicking substances.
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