期刊
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
卷 24, 期 7, 页码 711-717出版社
OXFORD UNIV PRESS
DOI: 10.1093/arclin/acp063
关键词
Working memory; Executive function; Information processing speed; Parkinson's disease; Neuropsychology
资金
- NIH [R01-NS050633, K23 NS060660-01, F32 AG021363-01, NIHK23 NS044997]
- National Parkinson Foundation Center of Excellence
- Michael J. Fox Foundation
- McKnight Brain Institute
- UF and Shands
- University of Florida Colleges of Medicine and Public Health and Health Professions
The n-back is a putative working memory task frequently used in neuroimaging research; however, literature addressing n-back use in clinical neuropsychological evaluation is sparse. We examined convergent validity of the n-back with an established measure of working memory, digit span backward. The relationship between n-back performance and scores on measures of processing speed was also examined, as was the ability of the n-back to detect potential between-groups differences in control and Parkinson's disease (PD) groups. Results revealed no correlation between n-back performance and digit span backward. N-back accuracy significantly correlated with a measure of processing speed (Trail Making Test Part A) at the 2-back load. Relative to controls, PD patients performed less accurately on the n-back and showed a trend toward slower reaction times, but did not differ on any of the neuropsychological measures. Results suggest the n-back is not a pure measure of working memory, but may be able to detect subtle differences in cognitive functioning between PD patients and controls.
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