Estimation of the proton affinity values of fifteen matrix-assisted laser desorption/ionization matrices under electrospray ionization conditions using the kinetic method

The kinetic method, which is known to be simple, fast and precise, is used for the measurement of proton affinity values of fifteen selected matrix-assisted laser desorption/ionization matrices under electrospray ionization conditions. The stabilization of [M - H](-)/[M + Matrix - H](-) ions for beta-cyclodextrin in negative ion mode has been rationalized based on the proton affinity values of the matrices. (C) 2004 American Society for Mass Spectrometry.