期刊
NEUROPHARMACOLOGY
卷 46, 期 3, 页码 299-310出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2003.09.016
关键词
cAMP-dependent protein kinase (PKA); A-kinase anchoring protein (AKAP); cAMP; neuron; synaptic plasticity; learning and memory
资金
- NIDDK NIH HHS [DK44239] Funding Source: Medline
- NINDS NIH HHS [NS045513-01] Funding Source: Medline
Significant progress has been made toward understanding the mechanisms by which organisms learn from experiences and how those experiences are translated into memories. Advances in molecular, electrophysiological and genetic technologies have permitted great strides in identifying biochemical and structural changes that occur at synapses during processes that are thought to underlie learning and memory. Cellular events that generate the second messenger cyclic AMP (cAMP) and activate protein kinase A (PKA) have been linked to synaptic plasticity and long-term memory. In this review we will focus on the role of PKA in synaptic plasticity and discuss how the compartmentalization of PKA through its association with A-Kinase Anchoring Proteins (AKAPs) affect PKA function in this process. (C) 2003 Elsevier Ltd. All rights reserved.
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