期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 75, 期 3, 页码 400-407出版社
WILEY
DOI: 10.1189/jlb.0503233
关键词
innate-immune system; adaptive-immune system; inflammation; SIRS; CARS; cytokines
资金
- NIGMS NIH HHS [GM35633, GM57664] Funding Source: Medline
Although we tend to think that the immune system has evolved to protect the host from invading pathogens and to discriminate between self and nonself, there must also be an element of the immune system that has evolved to control the response to tissue injury. Moreover, these potential immune-regulatory pathways controlling the injury response have likely coevolved in concert with self and nonself discriminatory immune-regulatory networks with a similar level of complexity. From a clinical perspective, severe injury upsets normal immune function and can predispose the injured patient to developing life-threatening infectious complications. This remains a significant health care problem that has driven decades of basic and clinical research aimed at defining the functional effects of injury on the immune system. This review and update on our ongoing research efforts addressing the immunological response to injury will highlight some of the most recent advances in our understanding of the impact that severe injury has on the innate and adaptive immune system focusing on phenotypic changes in innate immune cell responses to Toll-like receptor stimulation.
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