期刊
JOURNAL OF CELL SCIENCE
卷 117, 期 7, 页码 1269-1280出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.00970
关键词
human embryonic stem cell; noggin; bone; morphogenetic protein; extra-embryonic endoderm; neural; differentiation
类别
资金
- NIGMS NIH HHS [GM68417] Funding Source: Medline
Human embryonic stem cells differentiate spontaneously in vitro into a range of cell types, and they frequently give rise to cells with the properties of extra-embryonic endoderm. We show here that endogenous signaling by bone morphogenetic protein-2 controls the differentiation of embryonic stem cells into this lineage. Treatment of embryonic stem cell cultures with the bone morphogenetic protein antagonist noggin blocks this form of differentiation and induces the appearance of a novel cell type that can give rise to neural precursors. These findings indicate that bone morphogenetic protein-2 controls a key early commitment step in human embryonic stem cell differentiation, and show that the conservation of developmental mechanisms at the cellular level can be exploited in this system - in this case, to provide a facile route for the generation of neural precursors from pluripotent cells.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据