Preliminary evaluation of the antihepatotoxic activity of Kamilari, a polyherbal formulation

Hepatoprotective efficacy of Kamilari, a polyherbal preparation was studied in carbon tetrachloride (CCl4)-induced liver dysfunction in albino rats by determining different biochemical parameters in serum and tissues. In serum, the activities of enzymes like aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and the concentrations of protein and bilirubin were evaluated. The concentrations of total lipids, cholesterol, triglycerides (TG) and phospholipids were studied in serum and different tissues. Here, a dose-dependent study was conducted and oral administration of Kamilari at a dose of 750 mg/kg body weight significantly reduced the toxic effects of CCl4. From the observations, the conclusion drawn is that Kamilari stabilized the hepatic frame against the toxicity of CCl4. (C) 2003 Elsevier Ireland Ltd. All rights reserved.