MNGIE neuropathy: Five cases mimicking chronic inflammatory demyelinating polyneuropathy

We report five patients with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) who had demyelinating peripheral neuropathy. The MNGE neuropathy had clinical and electrodiagnostic features typical of acquired, rather than inherited, etiologies. In fact, three patients were actually treated for chronic inflammatory demyelinating polyneuropathy (CIDP) We discuss findings that may help distinguish patients with MNGIE from those with CIDP.