Effect of resistance training on skeletal muscle-specific force in elderly humans

This study assessed muscle-specific force in vivo following strength training in old age. Subjects were assigned to training (n=9, age 74.3+/-3.5 yr; mean+/-SD)and control (n=9, age 67.1+/-2 yr) groups. Leg-extension and leg-press exercises (2 sets of 10 repetitions at 80% of the 5 repetition maximum) were performed three times/wk for 14 wk. Vastus lateralis (VL) muscle fascicle force was calculated from maximal isometric voluntary knee extensor torque with superimposed stimuli, accounting for the patella tendon moment arm length, ultrasound-based measurements of muscle architecture, and antagonist cocontraction estimated from electromyographic activity. Physiological cross-sectional area (PCSA) was calculated from the ratio of muscle volume to fascicle length. Specific force was calculated by dividing fascicle force by PCSA. Fascicle force increased by 11%, from 847.9+/-365.3 N before to 939.3+/-347.8 N after training (P<0.05). Due to a relatively greater increase in fascicle length (11%) than muscle volume (6%), PCSA remained unchanged (pretraining: 30.4±8.9 cm(2); posttraining: 29.1±8.4 cm(2); P>0.05). Activation capacity and VL muscle root mean square electromyographic activity increased by 5 and 40%, respectively, after training (P<0.05), indicating increased agonist neural drive, whereas antagonist cocontraction remained unchanged (P>0.05). The VL muscle-specific force increased by 19%, from 27+/-6.3 N/cm(2) before to 32.1+/-7.4 N/cm(2) after training (P<0.01), highlighting the effectiveness of strength training for increasing the intrinsic force-producing capacity of skeletal muscle in old age.