期刊
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
卷 15, 期 2, 页码 165-169出版社
SOC BRASILEIRA QUIMICA
DOI: 10.1590/S0103-50532004000200002
关键词
Biginelli reaction; multicomponent reaction; dihydropyrimidinones; tin(II) chloride hydrate; Lewis acid
The ability of SnCl2.2H(2)O as catalyst to promote the Biginelli three-component condensation reaction from a diversity of aromatic aldehydes, ethyl acetoacetate and urea or thiourea is described. The reaction was carried out in acetonitrile or ethanol as solvents in neutral media and represents an improvement of the classical Biginelli protocol and an advantage in comparison with FeCl3.6H(2)O, NiCl2.6H(2)O and CoCl2.6H(2)O which were used with HCl as co-catalyst. The synthesis of 3,4-dihydropyrimidinones was achieved in good to excellent yields.
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