期刊
NEUROREPORT
卷 15, 期 3, 页码 519-521出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200403010-00027
关键词
anti-beta-endorphin antibody; cocaine dose-response; cocaine self-administration; beta-endorphin; maintenance; nucleus accumbens
Endogenous beta-endorphin levels in the brain are elevated in response to cocaine and are downstream of the mesolimbic dopaminergic system. However, beta-endorphin's direct involvement in cocaine reinforcement has not been demonstrated. In the present study, a single bilateral microinjection of anti-p-endorphin antibodies (4 mug) to the nucleus accumbens during the maintenance phase of cocaine self-administration (1 mg/kg/infusion) significantly increased the number of active and inactive lever responses. The increase in lever responses is reminiscent of rat behavior during extinction of cocaine self-administration. Further, a cocaine dose-response demonstrates that the increased lever presses in anti-beta-endorphin antibody-injected rats was still present after substitution with a lower dose of cocaine. These findings support a critical role for beta-endorphin in the cocaine brain reward system.
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