Biochemical markers of aquatic environment contamination -: Cytochrome P450 in fish.: A review

The paper reviews the most recent data on the role of cytochrome P450 as a biochemical marker of aquatic environment pollution. The important chemical characteristics of cytochrome P450, classification of its isoforms, its functions and involvement in the metabolism of endogenous and xenobiotic agents are described as well as methods for assessment of cytochrome P450 in biological materials. The main attention is paid to the CYP 1A isoform whose detection in fish is used in toxicological monitoring of ecosystems.