期刊
CARDIOVASCULAR PATHOLOGY
卷 13, 期 2, 页码 63-70出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S1054-8807(03)00130-3
关键词
modulator; mutant mouse; regulation; vascular calcification
资金
- NHLBI NIH HHS [R01 HL081785, R01 HL062329] Funding Source: Medline
Vascular calcification is highly correlated with cardiovascular disease (CVD) and is a significant predictor of cardiovascular events, especially in high risk patients such as the end stage renal disease (ESRD) population. Vascular calcification can lead to serious problems including valve stenosis, decreased vascular compliance, calciphylaxis, and even sudden death. However, the contribution of vascular calcification to progression of atherosclerosis is unknown and needs more study. Biochemical, histological, and genetic studies indicate that vascular calcification is actively regulated and involves both positive and negative modulators. Several nonmutually exclusive theories to account for vascular calcification based on current studies are discussed. (C) 2004 Elsevier Inc. All rights reserved.
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