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BRITISH JOURNAL OF SURGERY
卷 91, 期 3, 页码 327-333出版社
JOHN WILEY & SONS LTD
DOI: 10.1002/bjs.4429
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Background: It is important to identify patients at high risk of extrahepatic recurrence after surgery for liver metastases, in order to maximize the survival benefit obtained by prophylactic regional chemotherapy. Methods: Data from 68 patients who underwent resection of colorectal liver metastases but who did not receive hepatic arterial chemotherapy or intravenous systemic chemotherapy were collected. Twenty-two variables were examined by univariate and multivariate analyses to determine which factors were relevant to extrahepatic recurrence. A scoring system was developed that included the most relevant factors. Results: The extrahepatic recurrence rate at 3 years after hepatectomy was 57.8 percent. Three variables were independently associated with extrahepatic recurrence including raised serum level of carcinoembryonic,antigen after hepatectomy (relative risk (RR) 5.4, P < 0.001), venous invasion of the primary tumour (RR 4.0, P = 0.001) and high-grade budding of the primary tumour (RR 3.1, P = 0.006). Patients with none of these risk factors had a 3-year extrahepatic recurrence rate of 7.1 percent, compared with 61.6 per cent for those with one risk factor and 100 per cent for those with two or three risk factors. Conclusion. It was possible to identify patients at high risk of disease relapse at extrahepatic sites. This system might be used on an individual basis to select patients with colorectal liver metastases for regional chemotherapy or systemic chemotherapy after surgical intervention.
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