期刊
JOURNAL OF CLINICAL EPIDEMIOLOGY
卷 57, 期 3, 页码 223-228出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jclinepi.2003.07.009
关键词
randomized controlled trial; changes; analysis of covariance; regression to the mean; dichotomous outcome variables; continuous outcome variables; multinomial logistic regression
Objective: The most common way to evaluate the effect of an intervention is to compare the intervention and nonintervention groups regarding the change in the outcome variable between baseline and follow-up; however, there are many different ways to define changes. The purpose of this article is to demonstrate how different definitions of change used in the analysis can influence the results of a study. Study Design and Setting: Two different randomized controlled trials were used as examples. Results: The results of the analyses showed that for continuous outcome variables, analysis of covariance seems to be the most appropriate because it corrects for the phenomenon of regression to the mean. For dichotomous outcome variables, multinomial logistic regression analysis with all possible changes over time as outcome seems to be the most appropriate, especially because of its straightforward interpretation. Conclusion: A different definition of change can lead to different results in the evaluation of the effect of an intervention. (C) 2004 Elsevier Inc. All rights reserved.
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