Synthesis of some 2-[(benzazole-2-yl)thioacetylamino]thiazole derivatives and their antimicrobial activity and toxicity

Some 2-[(benzazole-2-yl)thioacetylamino]thiazole derivatives (III) were synthesized by reacting 4-methyl-2-(chloroacetylamino)thiazole derivatives (I) with benzazol-2-thiole (II) in acetone in the presence of K2CO3. The chemical structures of the compounds were elucidated by H-1 NMR and FAB(+)-MS spectral data. The prepared compounds were tested for antimicrobial activity and toxicity. (C) 2003 Elsevier SAS. All rights reserved.