期刊
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
卷 539, 期 2, 页码 187-195出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2013.06.003
关键词
Visual cycle; 11-Cis-retinal; 9-Cis-retinal; Vitamin A; Isomerase; Chaperone
资金
- Swiss National Science Foundation [PP00P2_139195, 31003A_130497]
- Swiss National Science Foundation (SNF) [PP00P2_139195, 31003A_130497] Funding Source: Swiss National Science Foundation (SNF)
We discuss here principal biochemical transformations of retinoid molecules in the visual cycle. We focus our analysis on the accumulating evidence of alternate pathways and functional redundancies in the cycle. The efficiency of the visual cycle depends, on one hand, on fast regeneration of the photo-bleached chromophores. On the other hand, it is crucial that the cyclic process should be highly selective to avoid accumulation of byproducts. The state-of-the-art knowledge indicates that single enzymatically active components of the cycle are not strictly selective and may require chaperones to enhance their rates. It appears that protein-protein interactions significantly improve the biological stability of the visual cycle. In particular, synthesis of thermodynamically less stable 11-cis-retinoid conformers is favored by physical interactions of the isomerases present in the retina with cellular retinaldehyde binding protein. (C) 2013 Elsevier Inc. All rights reserved.
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