期刊
BRITISH JOURNAL OF PHARMACOLOGY
卷 141, 期 5, 页码 775-785出版社
WILEY
DOI: 10.1038/sj.bjp.0705667
关键词
cannabinoid; glia; immune cells; inflammation; multiple sclerosis
资金
- NIDA NIH HHS [DA14486, R01 DA014486] Funding Source: Medline
- NIGMS NIH HHS [T32 GM07270, T32 GM007270] Funding Source: Medline
Growing evidence suggests that a major physiological function of the cannabinoid signaling system is to modulate neuroinflammation. This review discusses the anti-inflammatory properties of cannabinoid compounds at molecular, cellular and whole animal levels, first by examining the evidence for anti-inflammatory effects of cannabinoids obtained using in vivo animal models of clinical neuroinflammatory conditions, specifically rodent models of multiple sclerosis, and second by describing the endogenous cannabinoid (endocannabinoid) system components in immune cells. Our aim is to identify immune functions modulated by cannabinoids that could account for their antiinflammatory effects in these animal models.
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