期刊
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
卷 523, 期 1, 页码 123-133出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2012.04.001
关键词
Vitamin D receptor; Gene expression; Transcriptional factor; Calcium
资金
- Wisconsin Alumni Research Foundation
The vitamin D receptor (VDR) is a member of the nuclear receptor superfamily and plays a central role in the biological actions of vitamin D. VDR regulates the expression of numerous genes involved in calcium/phosphate homeostasis, cellular proliferation and differentiation, and immune response, largely in a ligand-dependent manner. To understand the global function of the vitamin D system in physiopathological processes, great effort has been devoted to the detection of VDR in various tissues and cells, many of which have been identified as vitamin D targets. This review focuses on the tissue- and cell type-specific distribution of VDR throughout the body. (C) 2012 Elsevier Inc. All rights reserved.
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