期刊
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
卷 524, 期 1, 页码 71-76出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2011.12.019
关键词
PTK7/Otk; Wnt; Frizzled; PCP
资金
- German Research Foundation (DFG)
PTK7 (protein tyrosine kinase 7) is an evolutionarily conserved transmembrane receptor with functions in various processes ranging from embryonic morphogenesis to epidermal wound repair. Here, we review recent findings indicating that PTK7 is a versatile co-receptor that functions as a molecular switch in Wnt, Semaphorin/Plexin and VEGF signaling pathways. We focus in particular on the role of PTK7 in Wnt signaling, as recent data indicate that PTK7 acts as a Wnt co-receptor, which activates the planar cell polarity pathway, but inhibits canonical Wnt signaling. (C) 2011 Elsevier Inc. All rights reserved.
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