期刊
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
卷 503, 期 1, 页码 20-27出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2010.06.027
关键词
Body composition; Lean mass; Osteoporosis; Insulin; Leptin; Amylin
资金
- Health Research Council of New Zealand
Body weight is a principal determinant of bone density and fracture risk, and adipose tissue mass is a major contributor to this relationship. In contrast, some recent studies have argued that fat mass after adjustment for body weight actually has a deleterious effect on bone, but these analyses are confounded by the co-linearity between the variables studied, and therefore have produced misleading results. Mechanistically, fat and bone are linked by a multitude of pathways, which ultimately serve the function of providing a skeleton appropriate to the mass of adipose tissue it is carrying. Adiponectin, insulin/amylin/preptin, leptin and adipocytic estrogens are all likely to be involved in this connection. In the clinic, the key issues are that obesity is protective against osteoporosis, but underweight is a major preventable risk factor for fractures. (C) 2010 Elsevier Inc. All rights reserved.
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