期刊
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
卷 36, 期 3, 页码 177-183出版社
OXFORD UNIV PRESS
DOI: 10.1093/abbs/36.3.177
关键词
DNA and RNA helicase; rnaleless (MLE); X-chromosome dosage compensation; dsRBD; RGG-box; transcription; RNA processing; RNA transport; actin; nucleolus; SLE (systemic lupus erythematosus); virus
Nuclear DNA helicase II (NDH II), or RNA helicase A (RHA), was initially discovered in mammals by conventional protein purification methods. Molecular cloning identified apparent sequence homologies between NDH II and a Drosophila protein named maleless (MLE), the latter being essential for the Drosophila X-chromosome dosage compensation. Increasing amounts of evidence suggest that NDH II is involved in multiple aspects of cellular and viral DNA and RNA metabolism. Moreover the functions of NDH II may have potential clinical implications related to viral infection, autoimmune diseases, or even tumorigenesis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据