期刊
CLINICA CHIMICA ACTA
卷 341, 期 1-2, 页码 139-146出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.cccn.2003.11.020
关键词
Down syndrome; oxidative stress; purine metabolism; uric acid; allantoin
Background: Down syndrome (DS) is a chromosomal abnormality (trisomy 21) leading to mental retardation, to the characteristic change of individual's phenotype and to the pathological features of Alzheimer disease. Patients with DS have elevated ratio of superoxide dismutase to (catalase plus glutathione peroxidase) with respect to controls in all age categories suggesting that oxidative imbalance contributes to the clinical manifestation of accelerated aging. Results: We report that persons with DS have elevated uric acid levels compared with controls, 348.56 +/- 22.78 versus 284.00 +/- 20.86 mumol/ 1 (p = 0.018). The levels of hypoxanthine and xanthine in DS children (6.35 +/- 0.31 and 1.02 +/- 0.23 mumol/l) were significantly lower than in controls (7.83 +/- 0.59 and 2.43 +/- 0.66 mumol/l). This result suggests increased conversion of hypoxanthine and xanthine to uric acid with subsequent free radical-dependent oxidation of uric acid to allantoin, mechanisms potentiated by the oxidative stress in DS. Allantoin is a nonenzymatic oxidative product of uric acid in human. In DS individuals, the levels of allantoin were significantly higher than those in healthy controls (18.58 +/- 2.27 and 14.07 +/- 1.07 mumol/l, respectively, p = 0.03). Conclusions: Our data supported the presumption of increased oxidative stress in DS. (C) 2004 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据