期刊
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
卷 484, 期 2, 页码 117-121出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2008.10.034
关键词
Tyrosine; Nitration; Nitrotyrosine; Peroxynitrite; Nitric oxide; Peroxidase; Oxidative stress
资金
- National Institutes of Health [HL54926]
- NIA [AG13966, ES013508]
- NIEHS Center of Excellence in Environmental Toxicology
Tyrosine nitration is a covalent post-translational protein modification derived from the reaction of proteins with nitrating agents. Tyrosine nitration has been used as a marker of oxidant burden in human diseases. However, it remains unclear whether protein nitration is responsible for alterations in protein function that imparts an increased risk for disease development or unfavorable outcomes. Emerging data implicate tyrosine nitration as a mediator of immune responses Suggesting a novel biological function for this protein modification. (C) 2008 Elsevier Inc. All rights reserved.
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