期刊
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
卷 473, 期 2, 页码 124-131出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2008.03.024
关键词
skeletal stem cell; tissue regeneration; osteoprogenitor; ex vivo expansion; bone tissue engineering; biomimetic scaffolds
资金
- Biotechnology and Biological Sciences Research Council [BBS/B/04269] Funding Source: Medline
- Biotechnology and Biological Sciences Research Council [BBS/B/04269] Funding Source: researchfish
Advances in our understanding of skeletal stem cells and their role in bone development and repair, offer the potential to open new frontiers in bone regeneration. Tissue engineering seeks to harness the regenerative capacity innate to bone for the replacement of tissue lost or damaged through a broad range of conditions associated with an increasingly aged population. The strategy entails ex vivo expansion of multipotential populations followed by delivery to the site of damage on dynamically durable-biodegradable three-dimensional structures which Provide the requisite extracellular microenvironment for stem cell driven tissue development. This review will examine bone stem cell biology, and current advances in skeletal tissue engineering through the enhancement and marrying of biologically informed and clinically relevant strategies. (C) 2008 Elsevier Inc. All rights reserved.
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