期刊
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
卷 476, 期 1, 页码 51-64出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2008.02.025
关键词
ABC proteins; P-glycoprotein; CFTR; MRP1; BCRP; mutational analysis; ATPase activity; cysteine mutagenesis; disulfide cross-linking; arginine mutagenesis
The 49 human members of the ATP-binding cassette (ABC) family of proteins are involved in a wide range of activities such as active transport of compounds across membranes, extraction of compounds out of membranes, functioning as ion channels, or regulators of channel activity. Mutations and/or overexpression of many of the proteins can have adverse effects on health. A goal in the study of ABC proteins is to understand their mechanisms of action. This review will focus on the mutational approaches that have been used to study the structure and mechanisms of some ABC proteins. (C) 2008 Elsevier Inc. All rights reserved.
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