期刊
NEUROSCIENCE LETTERS
卷 357, 期 2, 页码 91-94出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2003.11.016
关键词
milnacipran; hippocampus; CA1 field; long-term potentiation; 5-HT1A receptors; alpha(1)-adrenoceptors
Pharmacological characteristics of a serotonin (5-HT) and noradrenaline reuptake inhibitor (SNRI), milnacipran, in modulation of the synaptic plasticity were investigated. Milnacipran (30 mg/kg, i.p.) suppressed the long-term potentiation (LTP) in the hippocampal CA1 field of anesthetized rats. Milnacipran-induced suppression was reversed by pretreatment with the selective 5-HT1A receptor antagonist WAY 100635 (0.1 mg/kg, i.v.) or the alpha(1)-adrenoceptor antagonist prazosin (1 and 10 mug/rat, i.c.v.). The alpha(2)-adrenoceptor antagonist idazoxan (5 mg/kg, i.p.) did not influence the milnacipran-induced synaptic responses. These data suggest that the inhibitory effects of milnacipran on LTP induction are mediated via both 5-HT1A receptors and alpha(1)-adrenoceptors. In other words, functional interaction between the serotonergic and noradrenergic neuronal systems is involved in alteration of the hippocampal synaptic plasticity, which may be implicated in the SNRI-induced therapeutic effect on psychiatric disorders. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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