期刊
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
卷 476, 期 1, 页码 3-11出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2008.04.017
关键词
sarcoplasmic reticulum; Ca2+-pump; Ca2+-ATPase; membrane protein; muscle contraction; crystal structure; P-type ATPase; ion transport
Ca2+-ATPase of muscle sarcoplasmic reticulum is an ATP-powered Ca2+-pump that establishes a > 10,000-fold concentration gradient across the membrane. Its crystal structures have been determined for nine different states that cover nearly the entire reaction cycle. Presented here is a brief structural account of the ion pumping process, which is achieved by a series of very large domain rearrangements. (c) 2008 Elsevier Inc. All rights reserved.
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