期刊
CIRCULATION RESEARCH
卷 94, 期 4, 页码 420-432出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/01.RES.0000117583.66950.43
关键词
ischemia; reperfusion; mitochondria; ATP-sensitive potassium channels; calcium-activated potassium channels
资金
- NHLBI NIH HHS [R01-HL54598, R01 HL054598, R01-HL61711, R01 HL054598-09, R01 HL061711] Funding Source: Medline
Twenty years after the discovery of sarcolemmal ATP-sensitive K+ channels and 12 years after the discovery of mitochondrial K-ATP (mitoK(ATP)) channels, progress has been remarkable, but many questions remain. In the case of the former, detailed structural information is available, and it is well accepted that the channel couples bioenergetics to cellular electrical excitability; however, in the heart, a clear physiological or pathophysiological role has yet to be defined. For mitoK(ATP), structural information is lacking, but there is abundant evidence linking the opening of the channel to protection against ischemia-reperfusion injury or apoptosis. This review updates recent progress in understanding the physiological role of mitoK(ATP) and highlights outstanding questions and controversies, with the intent of stimulating additional investigation on this topic.
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