Basic alumina catalysed synthesis of substituted 2-amino-2-chromenes via three-component reaction

Substituted 2-amino-2-chromenes were obtained in excellent yield and selectivity simply by mixing malononitrile, alpha-naphthol and aromatic aldehydes in water in the presence of basic alumina as heterogeneous and reusable catalyst. (C) 2004 Elsevier Ltd. All rights reserved.