期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 14, 期 5, 页码 1139-1143出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2003.12.074
关键词
siRNA; phosphorothioate; biodistribution; planar imaging
资金
- NCI NIH HHS [CA 096354, P20 CA086354] Funding Source: Medline
- NICHD NIH HHS [HD 01463] Funding Source: Medline
- NIGMS NIH HHS [R01 GM060642, GM 60642] Funding Source: Medline
Short interfering RNAs (siRNAs) are valuable tools for analyzing protein function in mammalian cell culture. This success has led to high expectations for in vivo and therapeutic applications. However, the pharmacokinetic properties of siRNA are not known. Here we report the biodistribution of a phosphodiester (PO) siRNA duplex and examine the effect of phosphorothioate (PS) linkages. Our findings indicate that biodistribution of siRNA is similar to that for single-stranded antisense oligonucleotides and offer insights for use of siRNA in vivo. (C) 2003 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据